This year´s annual CEEGOG meeting is scheduled for December 8, 2023. Please save the date! The meeting is taking place in Prague at the Department of Obstetrics and Gynecology of the General University Hospital in Prague.      

Please do not miss the chance to include your proposals for new collaborative projects in the meeting agenda, and send your proposals to the CEEGOG office by the end of this October.   

We hope to meet you all personally this December, and to discuss research in gynecology oncology and the clinical trials conducted under the CEEGOG umbrella. 

The GCIG Spring meeting was held in Chicago on May 31 – June 1, 2023. CEEGOG was represented there by its Vice- Chair, Dr. Filip Frühauf, and by the CEEGOG Manager, Ivana Nohová, who attended the meeting as the online participants. 

As previously agreed, mostly academic studies were presented during the GCIG meetings. It provided a broader framework for discussion on the hot topics such as de-escalation of Parpi maintenance, benefit from densification of chemotherapy in patients with poor prognostic ovarian cancer, diversity of the HRD tests availbale, symptom benefit, toxicity of treatment and impact on daily activities to be measured by using the so- called MOST questionnaires which are validated instruments developed by GCIG.  

The need to conduct trials focusing on HRP/non-HRD patients, patients with DNA mutations associated with CCNE1 amplification and on the treatment of clear cell carcinoma was highligted. Further personalized medicine, quality of life measurements, ethical and race diversity were also stressed. 

Discussion about harmonization of documents used in international trials, patient involvement within clinical research, and trial budgeting were conducted. 

An update was provided on the Italian project to develop a deep learning system to predict the HRD status from ovarian cancer pathology slides, and on the preparation of the new integrated  guidelines of ESGO, EURACAN and WSN for uterina sarcoma. 

Further, it was proposed to establish an International Neoadjuvant Endometrial Cancer Consortium in order to avoid multiple small studies with heterogenous patient populations, interventions and differences in pathological assessment. 

The Endometrial cancer consensus conference 2023 is scheduled for November in South Korea. Two CEEGOG representatives, namely Dr. Zoltán Novák from Budapest and Dr. Filip Frühauf from Prague have been approved by GCIG to be part of the working groups. 

The Spring ENGOT meeting was held at the beginnning of this March in Milano. CEEGOG was represented by its Chairman Prof. David Cibula, Vice-Chairman Dr. Filip Frühauf and the administrative Manager Mrs. Ivana Nohová. On the first day, the meeting of operational representatives and also the strategic meeting were held. At the operational meeting, we discussed group experience with the CTIS, Regulatory Authority surveillance which is one of the Sponsor´s responsibilities for each trial. Further, the Irish group talked about green trials which focus on protecting the environment and mitigating the environmental burden of conducting clinical trials. Further discussion aimed at translational research, different group organisations and document sharing by groups.  

The assembly meeting was held on March 10, 2023. From the CEEGOG studies, an update on the FERTISS and SENTIX study was mentioned. Among the new trial ideas, the trials developed within the GCA academy held in December of last year were introduced.  

The ENGOT-ENYGO-GCA workshop was held in Malaga in December 2022. Prof. David Cibula appeared among the Tutors and Speakers and three CEEGOG representatives attended the workshop. Dr. Zoltán Novák from the Hungarian National Institute of Oncology in Budapest represented CEEGOG in working group 1 dealing with  PARPi maintenance after 1st line treatment in advanced/recurrent TP53-mutant endometrial cancer.This group also discussed the development of the phase Ib/II randomized clinical trial of Everolimus and Lenvatinib in patients with advanced endometrial cancer who had failed to the previous immunotherapy. This group discussion was guided by Prof. Mansoor Raza-Mirza. 

Dr. Oleksandr Zub from the Ukrainian site at the Chernihiv Regional Oncological Center was involved in  working group 2 focused on surgical treatment of recurrent, advanced and metastatic endometrial cancer under the leadership of Prof. Andreas du Bois. Dr. Filip Frühauf from the General University Hospital in Prague contributed to working group 4 aimed at evaluating of the role of post surgery systemic therapy in upfront or relapsed setting in patients with aGCT. Tthe discussion was managed by Prof. Isabelle Ray-Coquard. 

Prof. David Cibula chaired working group 6 focused on real world evidence on current ovarian cancer management in Europe. 

This year´s GCIG Autumn meeting was held in Berlin at the end of October. CEEGOG was represented there by its CEEGOG Manager, Mrs. Ivana Nohová, who was also invited to participate in a Brainstorming Session focusing on phase II trials. The discussion was targeted innovative phase II trial designs, how to integrate molecular biomarkers into phase II trial, how to use phase II to make a better phase III, how to design a clinical trial that is feasible in an international setting. The discussion conclusion will be summarized in a manuscript. 

Within the Harmonization operations committee meeting, Ivana Nohová delivered a presentation related to patient involvement within GCIG groups, the survey results thereon and their publication. During the Cervix committee meeting, she also provided an update on the recently initiated CEEGOG CX-05/ENGOT-cx16/CERVANTES trial to other GCIG groups.